The broadcaster said programmes such as Hollyoaks, Skins and Peep Show will be available on Google's video site once they've have been aired. It is expected that round 3,000 hours of programming will be available on YouTube.
Under the three-year deal Channel 4 will still be able to make the programmes available through other third parties.
"Making our programmes directly accessible to YouTube's 20 million UK users will financially benefit both Channel 4 and our independent production partners and help bolster our investment in quality British content," said Channel 4 chief executive Andy Duncan.
TV shows will be made available in the coming months, with the full catalogue expected online by early 2010.