Google Desktop now supports for Mac OS X 10.5 Leopard – which is launching tomorrow.
In addition to Leopard support, the newest Google Desktop for Mac update also allows indexing of drives where Spotlight has been disabled; Desktop no longer tries to index PGP disks; Time Machine won't back up Desktop indexes, nor will Desktop search Time Machine backups; and Desktop preferences pane now supports keyword searching in System Preferences for various settings.
There are also some architecture improvements in the new release. Google removed some Spotlight dependencies, removed the use of Input Managers, and they removed use of files in /System.
Google Desktop is a free download from the company's website.