Start by decluttering. If you've got files strewn all over your desktop, find them a permanent home in an appropriate folder. Create a folder, if needs be: right-click on the desktop, choose Create, New Folder and give it a name. Then drag items into it. Place useful shortcuts in the taskbar.
You can right-click on the desktop to bring up an option to run the Desktop Cleanup Wizard. This will gather up of all the infrequently used items and store them on your desktop in a folder labelled Unused Desktop Items. If they're unused, they shouldn't be there. Banish them to a folder, and delete any outdated files.
If you index your hard drive, moving files from disparate folders to a central location will be easier. Go to Start, Control Panel, double-click Administrative Tools and then Computer Management. Under Action, click Start or press the Play arrow. Run the process overnight if you've got a lot of data to index.
Get into the habit of labelling removable media, whether disc, USB key or flash memory card. This saves time when searching for archived content. The simplest method is to label by hand with an indelible pen. For DVDs, a LightScribe drive, such as the LG GSA-E10L, can burn a marker on the upper surface.
You can right-click to rename some removable media folders. Rename the photo folder on your SD Card, for example, before copying items to your PC. If all the folders are called V570 or another camera name, you'll soon get mixed up with similarly named folders from your camera.