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Mouse buttons no longer responding


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A problem I have never come across before; Windows Vista on a quad core Hewlett Packard with plenty of RAM and HDD space.

Without warning the mouse buttons have ceased to have any effect. The pointer moves fine, but trying to click on the start menu, on any icon, or anything at all (eg, if using menus in MS Word) produces no effect.

We have changed the mouse, but to to avail (the original mouse works fine on another computer) - so it is not the mouse. Interestingly, trying to use the Windows key also has no effect, so the only way of shutting down is to hold down the computer switch. When we re-boot it, the mouse may OK for a few minutes, then the buttons (both left and right) cease to (but the pointer still moves).

We have installed no new software, and all anti-virus and malware scans are up to date and show no problems. Googling the problem does not come up with anything meaningful. Any useful suggestions would be very much appreciated.

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