The setup my pc item must have put there by your vendor eg Dell etc... as it is not part of Windows.
Safely remove Hardware you need. I will either be for a removeable drive, printer perhaps, or some other item of hardware you have connected. If you wish to remove this item you right click the icon, left click the message that appears and choose the hardware you wish to unplug. Hardware should NOT be disconnected any other way.
Blocked start up programs could be any number of things. Do you have any in formation as to what they are. A box should pop up when you click this icon, or on start up.