If that's the resolution you run it at, it would drive me mad very quickly, not enough space!!
As for me, depends on what I am doing. I tend to run most apps full screen. When I'm shifting or processing files, I like the left half of the screen to have my local drives, and the right hand screen with the shares available on my network.
When video editing, I have a dual monitor setup so one screen will have the editing app running with the other dedicated to output or file management.
The short answer? Full Screen