You've changed the USB connection ? Changed the socket you plugged the USB wireless 'dongle' into ?
Have you got the red light from the mouse ?
Are the battery terminals clean ?
Are other things connected via USB eg printer or ext drive and are they working OK ?
If you think your USB needs a 'fix' try simply unpluging ALL the devices connected in the USB ports and uninstall the port from the 'Device Manager'. Restart the computer. The USB ports drivers will be re-installed when windows loads up at start up.