possible that the CD is damaged and your drives cannot acces/read the CD. Only way to tell is to try another machine to see is friends drive can access the CD.
Who makes Startrek Encyclopedia ?
I found it was by Grolier and aslo found refrence to Macintosh, must be more than 1 version.
Have you tried for a test turn off Pop up Blocker in the Internet property setings & Firwall. Re-boot pc then try it.
Also go into my computer then open the CD Drive which the CD is in and double click on the Start.exe icon