Eventually, but it has to be pretty 'dirty' before you would notice any difference.
"Can a complete novice clean the registry?"
Yes, by using software designed for the job - like CCleaner. I don't recommend that you touch the registry yourself.
What is ransomware and how do I protect my PC from WannaCry?
What I learned from my mentor, Oscar-winning VFX supervisor Phil Tippett
Siri vs Google Assistant
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