Short answer is no.
The longer answer is that Out of Office Assistant is only available with Outlook when it is uesd in an Exchange Server environmnet. Even if you swaped OE for Outlook at home OoOA would still not be available.
You can create rules that reply to messages saying you are away, but you would need to get OE to collect your emails and send the responses. If you are on dial-up this will be a problem.
A few months ago people were warned not to use OoOA or replies saying they would be away because of the potential security risks. Its the same reason why you cancel your milk/newspaper and some people ask the Post Office to keep back their mail until they are back.