If you are an audiophile with good HiFi and good ears then compression will always reduce the quality compared to what you can achieve in your home. It depends upon what you want to do - I can't carry my Quad pre and power amp + Quad speakers around with me but I can carry a 50 gram MP3 player with a set of 'on ear' rather than 'in ear' headphones weighing a few grams. The quality isn't superb but it's better than nothing. Perhaps however you might prefer nothing. It depends upon how much you are willing to compromise your audio quality for convenience.