Now that's a difficult one to answer as everyone will have their own opinions depending on the printer they have. For example I have three Epson printers and I have never had a problem with "dry out". I do tend to run a test print through them all at least once a week though. Not had too much experience of Canon printers, the last one I had (a long time ago) would only print black or colour, you had to change the cartridge every time. For example, if you wanted black you had to put the black cartridge in and if you wanted colour you had to take the black out and put the colour cartridge in. I think they have come a long way since then.