I am still with Win98SE... BUT
My 5500 scanner is SCSI and if you can load the Epson Twain32 driver it should work when called from Acquire (in Corel Photopaint)
Telling Windows it was an Epson 5500 did nothing for me!
Re-reading your question.... my scanner plugs in to a SCSI host card in a PCI slot on the computer, though my manual does mention that some (non-specified) on a list of Epson scanners will accept a bi-directional printer port, and my scanner does have an unused D-socket like a printer.... I use the 50 pin socket, but then I am sure my scanner is SCSI.