you'll need to supply some more information.
Are all your network machines from the same supplier?
Are they all about the same in terms of hardware and software configurations?
Are they all running the same operating system version?
Are desktop users permitted to make hardware or software configuration changes?
Do you have in-house IT support staff?
How many machines are on the network, and do you have any sub-nets?
What is your file backup procedure?
Provide answers to those questions and I'll be better placed to respond to your question.