Yes, you could and its pretty easy. FrontPage has a lot of built in framesets to choose from.
A link to look at is click here for a visual aid to ceating your own frames in FrontPage.
A word or three of warning: frames are well past their sell by date and have a whole load of potential problems to contend with. One of the biggest is search engine indexing for site recognition and this is not to be sniffed at.
Tables are by far the best way of laying a site out in static HTML or XHTML and offer the very best control over layout, search engine recognition and browser software and its ability to 'read' and render the age properly.
An inline frame tutorial is click here
This could work where you main page [top, left navigation and bottom footer area] remain the same and all content is loaded into one frame in the middle of the screen.
I'd still suggest that you stick with tables though.