Most C: drives, well mine anyway, are too large at 10+Gb to cram on a single memory stick.
(Yes I realise mem sticks are doubling and redoubling in capacity at a price!)
I will stay with proven technology until Im convinced that -
A.) Mem sticks are as dependable as HDs
B.) The price for very large capacity sticks has dwindled to make them a good buy.
I do use sticks, but for transferring chunks of data to another computer.