Ummm you could try and see what Photoshop (or similar editing program) could do.
But I'm guessing its not possible, because in Macro mode, the focus range is very short, typically 1-5cm. If your photo is not focused correctly when taken, it is unlikely that the computer can refocus it.
Its the same the other way round (ie, 'normal' mode taking a macro shot), if your picture is not focussed, it will be blurred. Photo editing programs might be able to cope with some blurring but not extremely out of focus images.