AdFender is a straightforward ad blocker which works with just about any browser, and requires the minimum of setup - just install the program, restart any open browsers and you should find ads in web pages are blocked immediately.
The program has been around for a long time, but development doesn't seem to have slowed, quite the opposite - version 1.75 adds some very significant improvements. There's support for 64-bit browsers in general, for instance. AdFender now works with AOL Browser, Ice Dragon and Waterfox. A malware domains filter list helps to keep you safe online. Improved content support (gzip, deflate) delivers better results, and there's improved performance, too.
Does it work? To an extent. We noticed a significant difference immediately, with the enormous majority of ads (not quite all, but near enough that you won't care) disappearing, all without you having to do anything at all. This speeds up your browsing by reducing the amount of data you're downloading, too, and hovering a mouse cursor over the AdFender system tray icon will show you a tooltip with the total amount you've saved too far.
There are also problems, though. AdFender works as a content filter, stripping out anything which looks like an ad, and very occasionally this produces undesirable results. The very first test link we clicked on, for instance, led us to Handbag.com, and when filtering was turned on the site became a mess. The multiple columns were lost, with stories simply appearing one above the other, making it a nightmare to browse.
You might be luckier, of course, depending on the sites you visit. And if not, you can create custom filters to block ads on some sites, and not others. That's suddenly not looking quite as straightforward, of course, but the option is there if you need it.