CoffeeCup Visual Site Designer uses a WYSIWYG approach to make it easy to build websites, even if you don't know anything about HTML.
The process starts by selecting one of 10 bundled themes, which define the colour scheme, look and feel of your site. Some are a little old-fashioned and basic, but there are more available if you need them (and you can alternatively start with a blank page and create your own look, if you prefer).
If you're looking to add a little extra interactivity to your site, then Visual Site Designer can insert a Flash object at the click of a button.
And when you're finished, the program's built-in FTP tool can even upload the site to your server, getting it online with the minimum of hassle.